Uncovering the links between diet, gut health, and immunity

الكشف عن الروابط بين النظام الغذائي وصحة الأمعاء والمناعة Nature Communications (2022). DOI: 10.1038 / s41467-022-31761-y” width=”800″ peak=”530″/>

A mannequin of a high-protein food regimen within the induction of the sIgA response. Feeding a high-protein food regimen enhances the manufacturing of succinate by the intestine microbiota. Excessive ranges of luminal succinate result in microbial mobile stress of the intestine and manufacturing of reactive oxygen species (ROS), which promotes vesicle formation and will increase manufacturing of bacterial-derived extracellular vesicles. Bacterium-derived extracellular vesicles can instantly activate TLR4 expressed within the intestinal epithelium, resulting in activation of downstream NFκB signaling that results in elevated expression of APRIL, CCL28 and PIGR, leading to a T-cell-independent sIgA response. Elevated TLR4 signaling additionally potentiates pro-inflammatory responses, resulting in DSS-induced colitis. The elevated intestinal succinate noticed in IBD sufferers might contribute to the pathology of the illness by enhancing the manufacturing of germ-derived extracellular vesicles and the TLR4/NFκB signaling pathway. attributed to him: Nature Communications (2022). DOI: 10.1038 / s41467-022-31761-y

A preclinical examine from the College of Sydney discovered {that a} high-protein food regimen can alter the microbiome within the intestine, triggering an immune response. The researchers say the examine brings us one step nearer to understanding the best way food regimen impacts intestine well being and immunity.

“The main focus of our work is on how the intestine microbiota – the trillions of micro organism that reside within the intestine – impacts the immune system,” mentioned Affiliate Professor Lawrence Macia of the Charles Perkins Middle and College School of Medication and Well being.

“Our final purpose is to grasp how we are able to manipulate micro organism to enhance well being, and we all know that one of many best methods to alter microbiota is to alter the food regimen.”

Nevertheless, scientists have historically centered on the position of dietary fiber in sustaining a wholesome intestine.

On this examine, the primary of its variety, revealed in Nature CommunicationsIn mice, the Charles Perkins Middle workforce used refined modeling to discover the impact of 10 diets with totally different combos of macronutrients – protein, fats and carbohydrates.

They found {that a} high-protein food regimen alters the composition and exercise of the intestine microbiota.

Mice fed a high-protein food regimen elevated their manufacturing of extracellular bacterial vesicles, a posh payload that incorporates bacterial info resembling DNA and protein. The physique then seen this exercise as a risk and triggered a sequence of occasions as immune cells journey to the intestinal wall.

“We discovered right here that protein had a major impact on the intestine microbiota and it was not associated to the kind of micro organism there, however slightly the kind of exercise. Primarily, we found a brand new manner of communication between intestine micro organism and a protein-mediated host,” mentioned Affiliate Professor Masia.

Whereas it is too early to say whether or not this analysis may translate in people, the researchers say that activating the immune system might show to be both good or dangerous information.

“By growing the antibodies within the intestine, you might even see sturdy safety in opposition to potential pathogens, for instance salmonella, however on the draw back, an energetic immune system might imply you might be at elevated danger of growing colitis, inflammatory bowel illness, or autoimmune illness.” Like Crohn’s illness, lead creator and postdoctoral researcher Jian Tan mentioned.

The outcomes seem in keeping with the demographic impacts of contemporary diets, with the Western world experiencing decrease charges of gastrointestinal an infection however increased charges of persistent illness.

This advance in data was made doable by incorporating the tutorial disciplines for which the Charles Perkins Middle turned recognized.

The examine used the engineering framework for diet developed by Professor Stephen Simpson and Professor David Rubenheimer, arising from the examine of ecology.

Professor Simpson mentioned: “The ‘meals engineering’ framework permits us to plan meals, meals, diets and dietary patterns collectively based mostly on their dietary composition, and this helps researchers to notice in any other case missed patterns within the hyperlinks between sure diets and well being and illness.” , Tutorial Director of the Charles Perkins Middle.

“That is the primary time this mannequin has been utilized in immunology and it may possibly solely occur right here on the Charles Perkins Centre. We’re enthusiastic about what might occur subsequent,” Affiliate Professor Masia mentioned.


Food plan beats anti-aging medicine and good metabolic well being


extra info:
Jian Tan et al., Dietary protein will increase T-cell-independent sIgA manufacturing by means of modifications in extracellular vesicles derived from the intestine microbiota, Nature Communications (2022). DOI: 10.1038 / s41467-022-31761-y

Offered by the College of Sydney

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